Thursday, November 28, 2019
Glutten Free, Sugar Free, Low Carb Cake Balls free essay sample
So have you ever been to a party where there were cake balls and they were so good that you couldnââ¬â¢t stop eating them? Well I have and I know that I donââ¬â¢t like how I feel after I eat all of them. After going to a couple of different parties where these addicting treats were present I decided that I needed to find a way to make them better for you while still maintaining there amazing great taste. So I did some research with my kid sister and we found the perfect recipe. This amazing recipe is gluten free, sugar free, and it is also low carb. Today Iââ¬â¢m going to inform you on how to make this fabulous batch of cake balls, which is set to make fifty. a. First I will tell you the differences in a batch of cake balls from a box cake and the healthy cake balls Iââ¬â¢m going to give you. We will write a custom essay sample on Glutten Free, Sugar Free, Low Carb Cake Balls or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page i. First a box of cake mix is already mixed and ready to go not much of a hassle to make, but the healthy cake balls require you to mix a bunch of different ingredients together. While it is time consuming if your making them with a friend or with your family members then it would be a great way to bond and talk. Second the texture of the healthy cake balls is sort of rough because there is applesauce in it and a regular cake mix is going to be smooth and ââ¬Å"normalâ⬠. b. The second thing that Iââ¬â¢m going to inform you on is how to make the cake balls. i. First you need to make sure you have all your ingredients 1. Ingredients such as almond flour, unsweetened coco powder, sea salt, baking powder, applesauce, eggs, vanilla extract, raspberry fruit spread (no sugar added) ii. Next you have to pre-heat the oven to 350à °. You also need to have a 139-baking pan to put the cake mix to place in the oven. You then have to combine all your dry ingredients together in a large mixing bowl, and in a medium bowl mix together all your wet ingredients. iv. After you have mixed the dry and wet ingredients separately slowly mix them together into the large mixing bowl until thoroughly combined. Then pour into the baking pan. v. Once the cake has baked for roughly thirty-five minutes (or until toothpick comes out clean) let the cake cool off completely before you crumble the cake into a large bowl and mash the raspberry spread. Now that you know how to make the mix for cake balls you just have to form them and add a candy coating. i. Once the mixture is completely mixed take it and start making one-inch balls then put a lolli stick in it. ii. The candy coating is just an unsweetened 100% Cacao chocolate baking bar melted with vanilla extract. All you have to do is simply dip the stick into the melted chocolate (or your choice of flavor) III. Conclusion: Now that you know how to make healthy gluten and sugar free, low carb cake balls, you can be the one to bring them to parties and share the recipe.
Sunday, November 24, 2019
1993 Ap Us History Dbq Essay Example
1993 Ap Us History Dbq Essay Example 1993 Ap Us History Dbq Essay 1993 Ap Us History Dbq Essay Essay Topic: Us History During the 17th century there were many colonies settled in the New World. One thing most of these colonies had in common is the fact that almost all of them were settled by the English. If one were to focus mostly on the New England and Chesapeake colonies, one would find that although they were settled by similar people, they ended up splitting for very different reasons. The New England colonies were searching for religious freedom from the Church of England, whereas the Chesapeake colonies were striving for economic growth. The New England colonies consisted of the settlements of Massachusetts Bay Colony, Connecticut Colony, Colony of Rhode Island and Providence Plantations and Province of New Hampshire. Most, if not all, of these colonies were mainly settled by religious motivation. They did not want to be told by what means they could or could not worship, that was the reason they left England in the first place. Now in this new world they were being given the same rules. They wanted to control their cities by the rules of God that they believed. They wanted to elect their own faithful minister to make the laws and divide up their real estate (Doc D). They also wanted to follow John Winthropââ¬â¢s idea of a model puritan city, the ââ¬Å"City on a Hillâ⬠(Doc A). The first name on a list of emigrants coming to the New England was Joseph Hull of Somerset, he was a Minister. His name was the very first name on the list, therefore his name was the most prominent name on the list, and he was a minister (Doc B). This shows that the New England colonist truly respected members of the clergy. The Chesapeake colonies were settled for very different reasons. They were mainly settled for economic development and prosperity. In many of the Chesapeake colonies, such as Connecticut, the prices and wages were set and agreed upon by the court. They did not have any religious figures decided laws or actions to carry them out. Many of the tradesmen, as well as the laborers, in Connecticut were told to ââ¬Å"consider the religious ends of their callingâ⬠and to ââ¬Å"[not] live in the practice of that crying sin of oppression, but avoid itâ⬠(Doc E). This means that they were told to end their religious practices but to also avoid the life of sin. By doing this, they made room for more work which would in turn help the settlement prosper economically. There were also many plantations in the Chesapeake colonies. These plantations grew tobacco which inclined many workers to uphold the demand. This helped to draw in many English workers, as well as African Slaves, which ended up helping the economic growth of the colony overall. Lastly, both settlements were colonized by two different types of people, with extremely different motives. The Chesapeake colonies, such as Virginia and Maryland, were colonized by single men looking for the potential development of economic growth, and the ability to make a profit. Whereas the New England Colonies, such as Rhode Island, were colonized by family men looking for a place where their family could be free from religious oppression. Virginia was colonized by John Smith, a single man who saw the opportunity to make some money and did everything in his power to keep the colony alive in order to do so. Maryland was colonized by Lord Baltimore, another single man who granted real estate to his friends which paved the way for economic growth. Although the New England colonies and the Chesapeake colonies were both settled by Englishmen, they split for very different, but equally legitimate reasons. The New England colonies were searching for religious freedom from the Church of England, whereas the Chesapeake colonies were striving for economic growth.
Thursday, November 21, 2019
Heat Exhaustion Essay Example | Topics and Well Written Essays - 750 words
Heat Exhaustion - Essay Example Sunburns, heat cramps, heat stress, heat stroke and heat exhausting are some of the heat related disorders. While the symptoms and treatment may differ, in each case there is overexposure to heat or the person has over exercised for his/her age and physical condition in the existing thermal environment. Heat exhaustion is caused by a loss of salt and water from the body usually through excessive sweating (SJA, 2007). Severe debilitation occurs due to extreme body heat. Excessive heat and dehydration cause the body temperature to rise above 102 degrees (Alonzo, 2003). While the causes of heat exhaustion can be many, there are various ways in which people can protect themselves from the effects of prolonged exposure to extreme heat. The symptoms of heat exhaustion include paleness, nausea, extreme fatigue, dizziness, light-headedness, or even vomiting, fainting and cool and clammy skin (Alonzo). The treatment and prevention are issues which should be known to every individual. If the victim is out in the sun, he/she should be brought out of the sun and made to lie down after loosening the clothes preferably in an air conditioned room. Wet cloth should be applied and urged to take frequent sips of water. If this causes nausea then water sips have to be discontinued. Medical attention may be required if vomiting persists. There are various ways in which the people themselves or the organizations can reduce or even prevent heat exhaustion. First and foremost the body should be allowed to acclimatize to the difference in temperature especially for those who are not used to working in hot environment (Dresser). They have to get accustomed to working in the heat which normally takes a week or two to get used to. Reducing the physical demands of the job for a week or two allows a worker to acclimatize. Cool shady environments are prerequisites for prevention of heat exhaustion. Secondly, the body has to be well hydrated and this means
Wednesday, November 20, 2019
King Leopold's Ghost by Adam Hochschild Essay Example | Topics and Well Written Essays - 750 words
King Leopold's Ghost by Adam Hochschild - Essay Example Apparently, industrial revolution became a major tool of change among the whites and the blacks. So many Africans became sycophants of white rulers simply because of the nature of their rule. In addition, a strong relationship existed among the whites and the colonialists that gave the blacks a recognizable strategy of making sure that some issues were approached in a technologically sound way. Some items of trade like ivory, rubber, guns, and steam boats were mainly used by colonialists to enhance their strategy and to provide a better way of realizing their goals. During that particular era, slaves were the main target for colonial masters (Hochschild 33). Also, new technologies facilitated colonization process by making sure that all the colonial territories were managed in a highly controllable manner. With the use of guns, colonial masters engaged in superior war tactics that finally created a territorial battle among the colonial masters. Most of the colonial masters participat ed in a process that gave an indication of where various communication strategies were practiced. With the kind of knowledge that was available by then, many European powers decided to practice the act of ruling Africa with an iron fist. With the use of technology not withstanding, there was an indication that many countries in African were not ready for any kind of kind of leadership that could ruin their action. Use of superior weapons such as guns and effective means of transport gave the colonialists the power to control the Africans in a manner that reflected strong urge for leadership. Industrial revolution offered many African nations an opportunity to understand the strength of colonial masters. All the relevant aspects were considered by colonial masters. It is undeniable to point out that all the aspects of colonialism originated from the desire by colonial masters to offer the best of their services in Africa. Nevertheless, a substantial number of colonial groups based th eir success on the use of superior weapons and technology. A perfect illustration of technology application is when the Africans are colonized from a perspective that is not the will of the many local people (Hochschild 76). Again, the success of colonialists was significantly as a result of use of superior weapons. Africans were defeated on the grounds that many colonialists were using highly superior weapons. For example, there was no way an African was allowed to use a gun during the war. This was simply a strategy by many colonialists to avoid the undermining of public image. There was a perception by then that Africans could make easily in any battle if their weapons were crude and inferior. Also, the colonial masters in most parts of the African continent decided to investigate the influence caused by such kind of battles in common people. The outcome therefore revealed clearly that so many people within the continent had a strong perception about the colonialism and its negat ive effects. The ultimate impact of the technological approaches became the final indication of how African colonies could be ruled (Hochschild 45). The killing of many Congolese never appeared in the American news and media simply because African was perceived as a dark continent. The massacre went unnoticed and many people were killed with the use of superior weapons. Unlike the Nazi massacre in Germany, the killing of so many
Sunday, November 17, 2019
History of Education in USA Research Paper Example | Topics and Well Written Essays - 750 words
History of Education in USA - Research Paper Example He realized that different student had different academic needs and advocated activities in his curriculum. Jefferson pushed a system of education which accomplished the base of strong foundation of universities and colleges. In 1786 Benjamin Rush presented an educational system which he hoped would meet the needs of democratic ideology. He was of the view that the sanctuary of a nation lies in a proper education. He advocated education for both men and women to understand the principles of democracy and to implement it properly. Noah Webster, during his tenor, identified the need for schools to have text books in American language and experienced a conflict towards the British which they currently used. His unique achievement was American dictionary, which he created instead of following other dictionaries. The federal government has played its role to improve standard of education throughout America. They have strived to help citizen in getting better quality of education by lending extra money to those who need it. Most of the credit goes to G.I Bill, National Defence Education Act (NDEA), and the Elementary and Secondary Education Act (ESEA), because of which many Americans have been able to get higher education. Granting federal land to the states for educational purposes started with the Northwest ordinance of 1785. The G.I. Bill of rights is the base which worked as a lime stone for providing educational benefits for veterans of World War II. The general aim of this legislation has been to compensate veterans for their services and sacrifices. Many veterans took advantage from this Act and graduated from this program with prolific careers. Federal government also established number of schools for specific purposes and encouraged recreational education in acts as NDEA in 1958. Political dynamics laid hurdles in actions of federal aid legislation, but the situation changed when Soviet Union, rival of US created space satellite. Another act that promoted federal financial aids further, was ESEA of 1965. Where NSEA emphasized on science and math, ESEA responded to the prominent social change in society. The ESEA related to President Lyndon Johnson's program "War on Poverty" encouraged special programs for children of poor families. In 1981 this act was named chapter 1 of Educational Consolidation and Improvement Act (ECIA). (Christen Baylis-Heerschop, 2007). The National Service Legislation of 1993 (the National and Community Trust Act), and the Education of All Handicapped Children Act of 1975 (better known as Public Law 94-142) are merely current extensions of federal involvement in education that reaches back to American historical beginnings. The 1990 Individuals with Disabilities Education Act (IDEA) and the Education Amendments of 1997 extended provisions of Public Law 94-142 to all citizens from ages 2 to 21. Provisions of both acts are under continuing review by congressional committees to clarify various provisions. The acts require inclusion, or placing students with physical and emotional challenges in regular classrooms. The 2005 funding reauthorization act, "Improving Education Results for Children with Disabilities," expanded, defined, and clarified
Friday, November 15, 2019
Distal Symmetrical Neuropathy (DPN)
Distal Symmetrical Neuropathy (DPN) Abstract The most common complication of diabetes, distal symmetrical neuropathy (DPN), decreases quality of life and causes disability. Therefore, it hasa significant impact on social and economic aspects. Unfortunately, the treatment of this condition remains challenging because, apart from improving glycaemic control, there are currently no pathogenetic drugs that meet the requirement set by US regulation. This is not necessarily due to a lack of therapeutic potential, but because the endpoints were not robust enough to detect the therapeutic benefit. This essay will address several acknowledged surrogate endpoints (SE) for DPN. Corneal confocal microscopy will also be reviewed as a potential SE for DPN. Introduction Neuropathy, a common long-term complication of diabetes, is associated with the progressive loss of nerve fibres affecting both the somatic and autonomic nervous systems.1 The most common type of diabetic neuropathy is DPN, of which manifestation may vary from painful sensations to foot insensitivity at risk of ulceration.2 In an attempt to treat DPN, clinicians use symptomatic drugs such as tricyclic antidepressants, anticonvulsants, opioids, and opioid-like agents that alleviate painful symptoms in the lower limbs.3 These drugs, however, do not affect the underlying cause of the disease, which is believed to be progressive loss of nerve fibres. Drugs that target putative pathogenesis of the disease, therefore, may become great alternatives. There are currently two main experimental drugs that belong to this group: namely, antioxidant à ±-lipoic acid4 and aldose-reductase inhibitor epalrestat.5 However, although theyhave been approved in a limited number of countries, they fail to demonstrate sufficient efficacy to be approved by US regulation. This has raised a question about the reason behind this problem. Poorly designed trials, slow progression of the disease, relatively short duration of the trials, strong placebo effect, and endpoints selection are amongst the factors proposed behind this problem.6The latter factor is of particular interest because some of the current surrogate endpoints for DPN assessment may be subjective due to reliance on the patientââ¬â¢s response. Further discussion of SE for DPN will be reviewed below. Surrogate endpoints for DPN The endpoints used in clinical trialsare variable to evaluate the changes in patient condition after they have been given certain treatment. The ideal endpoints should be clinically meaningful and directly measure how the patients feel, function, and survive.7 However, it is difficult in some cases to apply them in clinical trials due to subjectivity or measurement difficulty. Moreover, the clinical trials have to be conducted overa very long periodto measure these ideal endpoints. To solve this problem, the researchers use the surrogate endpoints which define any laboratory measures, signs or symptomsthat are intended to be used as substitutes for clinically meaningful endpoints.7 Therefore, any changes in the surrogate endpoints induced by treatment are expected to reflect the changes in the clinically meaningful endpoints. In the case of DPN, several endpoints have been used to diagnose and evaluate progression or severity of the disease, including clinical assessment, electrophysiology, quantitative sensory testing (QST),8 sympathetic skin response (SSR),9 quantitative sudomotor axon reflex test (QSART),9, 10 autonomic testing, nerve/skin biopsy,11-13 and corneal confocal microscopy (CCM).14 Clinical assessment of DPN involves assessing the severity of the patientsââ¬â¢ symptoms and neurological examination. Most components of this examination rely on patientsââ¬â¢ responses and the physiciansââ¬â¢ experiences; therefore it has poor reproducibility and marked variation in inter-observer agreement.Dyck15 tried to overcome this problem by developing composite scores that assess the symptoms and signs of DPN. The neuropathy symptom score (NSS) was developed to assess the symptoms, whereas the neuropathy disability score (NDS) was devised as a quantified neurological examination.15 Later, NDS was replaced by the neuropathy impairment score (NIS).16 However, these scores still have a certain degree of subjectivity, meaning the evaluation of disease severity may be biased. An electrophysiology study measures the electrical conduction along the nerve fibres to evaluate their function. As a surrogate endpoint, it has been criticised due to the need for special equipment and a trained examiner.17 Moreover, there is evidence that it only assesses the function of large fibres,18 yet the earliest fibres affected by diabetes aresmall unmyelinated fibres.12 QST, on the other hand, evaluates both large (A-beta) and small (A-delta and C) nerve fibres. It measures sensory response after the application of accurately calibrated sensory (mechanical and thermal) stimuli.8 However, it has been criticised because it is subjective (based on patient response) and thus cannot differentiate between fake or real response. Due to this reason, QST results are not recommended to be the sole criteria to diagnose DPN. The combination of composite score, electrophysiology, and QST offers a relatively robust tool to define neuropathic severity but fails to detect the earliest sta ge of nerve damage that happens in small unmyelinated fibres.19 The somatic nerve disturbances due to diabetes are usually accompanied by vasomotor or sudomotor changes that suggest autonomic involvement. QSART examines the sudomotor changes in neuropathic patients by measuring sweat volume produced by skin after chemical10 or electrical stimulation.20 QSART is considered as a robust endpoint for DPN because it is quite sensitive, objective, and reproducible.9, 20 It has been shown to be able to detect C-fibres involvement in DPN patients who have otherwise normal neurological examinations and nerve-conduction studies.10 However, it requires special equipment and needs a relatively long time to be carried out. These drawbacks limit the application of QSART in clinical trials, especially if a large number of subjects are required. Sural-nerve biopsies and skin biopsies directly assess the damage and repair of small nerve fibres and have been proposed to be surrogate endpoints in clinical trials.11, 12Both of these methods have been shown to be very sensitive in detecting regeneration or abnormality insmall nerve fibres. The quantification of intra-epidermal nerve-fibre density (IENFD) from a skin biopsy, for example, is shown to be more sensitive than QSART and QST in diagnosing DPN.13 Nevertheless, the invasive nature of these procedures may become a problem, especially for diabetic patients. To solve this problem, anon-invasive measurement needs to be developed. CCM offers a new approach to directly measure the severity of DPN through visualisation of the subbasal nerve plexus in Bowmanââ¬â¢s layer of the cornea. The cornea is a highly innervated organ which contains dense A-delta and C-unmyelinated fibres. The question remains whether corneal innervation has a connection with neuropathy caused by diabetes. Recent evidence, however, shows that corneal sensation is impaired in both diabetic21 and galactose-fed rats.22Moreover, in diabetic patients the subclinical abnormalities of corneal innervations23 and corneal ulceration24 are commonly recognised. This is due to the progressive loss of corneal nerve fibres which in turn reduces the neurotrophic stimuli required to develop a healthy and thick corneal epithelium. In 2000, Rosenberg et al.25 found that corneal sensation and nerve-fibre number werereduced in patients with type I diabetes. Later, the degree of corneal-n erve-fibre loss was shown to correlate with the degree of DPN assessed by a combination of NDS, electrophysiology and QST.26 These suggest that diabetes may affect the corneal innervations and therefore it is possible to assess neuropathy through corneal-nerve-fibre evaluation. CCM assesses corneal nerve morphology by quantifying three different parameters: namely, corneal-nerve-fibre density (NFD), the total number of major fibres per square millimetre; nerve-branch density (NBD), the number of branches emanating from major nerve trunks per square millimetre; and nerve-fibre length (NFL), the total length of nerve fibres and branches per square millimetre.26Quattrini et al.14 provided further evidence that CCM parameters can be used to assess small-fibre damage in humans. Moreover, they found that CCM results correlated with IEFND, which was considered a robust tool to assess small-fibre damage. Later, a study in patients who underwent simultaneous kidney-and-pancreas transplantation showed that CCM was, in fact, more sensitive than IEFND to detect early nerve damage and regeneration.27 The role of CCM is not limited to evaluating the progression of disease;it can also be used to diagnose DPN and identify at-risk patients due to high sensitivity.28 These s uggest that CCM may be used as a tool to diagnose, identify at-risk patients, and evaluate nerve-fibre damage or repair. Recently, CCM has successfully detected corneal nerve damage which correlates with neuropathic measurements in several diseases other than diabetes, such as idiopathic small-fibre neuropathy,29 Fabry disease,30 and Charcott-Marie-Tooth type 1A disease.31The evidence so far shows that CCM may have the potential to be an ideal surrogate endpoint for DPN. It is sensitive, quantitative, highly reproducible, and noninvasive.32, 33However, more research is needed to establish a connection between CCM measurement and clinically meaningful endpoints which, in the case of DPN, are pain, disability, and the curtailment of quality of life. Conclusion Apart from the possibility that the tested drug may not yield the intended outcome, the failure to detect the effectiveness of experimental drugsmay, in case of DPN, be caused by improper selection of surrogate endpoints in clinical trials. There are currently several acknowledged surrogate endpoints for DPN, such as clinical assessment, electrophysiology, QST, QSART, SSR, monofilament test, nerve/skin biopsy, and autonomic testing.However, they have several drawbacks, such as being time consuming, subjective, and difficult to practice. Recently, CCM has emerged as a potential surrogate endpoint for DPN because it is non-invasive, highly reproducible, quantitative, and sensitive. However, more research is needed to establish its position as a game changer in neuropathy-outcome assessment.
Wednesday, November 13, 2019
Censorship of Pornography :: Social Issues Argumentative Censor Porn Essays
Censorship of Pornography Sex, Erotica, nude women, three some, these are some keywords for finding pornography on the internet. The censorship of pornography has a positive affect on the United States of America and is a good thing because pornography leads to crime, pornography has no positive effects on society, and censoring pornography is not against the constitution. Crimes and pornography have a direct and apparent link. Eighty-one percent of criminals rate pornography as their highest sexual interest ( ). This means that the clear majority of criminals love pornography and find it highly interesting, most other people probably rank other human beings as their highest sexual interest. When an adult book store is closed the crime rate in the surrounding areas falls significantly ( 188). Also It was found that child molesters have a higher probability of molesting a larger number of victims and it is likely that these offenders have some access to pornography or erotica. ( 189). Over all crime and pornography do have a link between them and that makes censoring it a positive idea for America. Pornography has no positive effect on society. The American population agrees that pornography does not serve a legitimate purpose. Seventy-two percent of Americans want some sort of crack down on pornography. Also Ninety-two percent of Americans want a crack down on child pornography because it has no value and is disgusting and against the law ( 179). Pornography was found to have little redeeming social value by artistic criteria and is close to worth less ( 218). The censoring of pornography is not against the United States Constitution. The reason why pornography is not included under the constitution is because it was demeaned by the United States Supreme court in 1973 to be lewd and obscene material ( 173). The first amendment was intended to protect political speech in America not the speech that includes the exploiting of women and photography of women being raped ( 183). The founding fathers did not intend for their bill of rights to be exploited in the ways that it is today they would have wanted us to have a safe and peaceful society. That would be one that does not include pornography. The opposition to the censoring of pornography will say that it is against the United States Constitution, which it is not. They will also say that it is censoring thoughts and ideas not actions.
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